Plague: One Scientist’s Intrepid Seek for the Fact About Human Retroviruses and Continual Illness

Plague: One Scientist’s Intrepid Seek for the Fact About Human Retroviruses and Continual Illness

Judy Mikovits, Ph.D., a virologist, researcher and founding analysis director of the Whittemore Peterson Institute — which researches and treats power fatigue syndrome (CFS) in Reno, Nevada — acquired embroiled in controversy when, in 2009, she was the senior writer on a paper which reported that a retrovirus often known as xenotropic murine leukemia virus-related virus (XMRV) might play a causal function in CFS and different ailments, together with autism.

Her e book, “Plague: One Scientist’s Intrepid Seek for the Fact About Human Retroviruses and Continual Fatigue Syndrome (ME/CFS), Autism and Different Illnesses,” particulars her analysis and private trials that arose as a consequence of her work.

“Kent Heckenlively primarily wrote it,” Mikovits says, “as a result of I write like a scientist. We wrote it utilizing the style of flashback. He taped hours and hours of me telling the story as he requested me questions — as a result of he is educated as an legal professional — after which he turned that into this suspense-thriller. Curiously sufficient, it nearly has to learn like fiction due to the attorneys it took to … be sure we weren’t sued.”

What Are Retroviruses?

Earlier than we go additional, let’s overview what a retrovirus is. A retrovirus is a ribonucleic acid (RNA) virus — in different phrases, a virus that accommodates RNA encoded genes somewhat than deoxyribonucleic acid (DNA). Utilizing reverse transcriptase, the retrovirus is ready to remodel the single-stranded RNA right into a double-stranded DNA.

When the retrovirus infects a number, it integrates its DNA into the DNA of the host cell, which permits the retrovirus to copy itself and unfold via the host. As an increasing number of cells are contaminated, you change into more and more sicker. Mikovits explains:

“People have a DNA genome. Our blueprint is DNA. Retroviruses have an RNA genome, however in addition they are distinctive within the RNA household of viruses, the place their RNA genome is reverse-transcribed. That’s, written backwards by an enzyme distinctive to retroviruses referred to as reverse transcriptase. That enzyme writes the RNA into DNA.

Then they’ve one other enzyme referred to as integrase. Integrase is sort of a pair of scissors that cuts open your DNA after which inserts the retrovirus, which is just about Eight,000 base pairs, a really, very, very small virus, 50 to 100 nanometers on an electron micrograph. That piece of DNA — referred to as a provirus — is now within the DNA of your cells endlessly. Each time your cells replicate, you make extra viruses.”

Now, this DNA insertion has been ongoing all through human historical past. Based on Mikovits, about 10 % of the human genome is retroviral in origin. These are referred to as human endogenous retroviruses. These, nonetheless, differ in that they have been crippled partly by our DNA methylation equipment (which modulates genes expression and the human immune system — in order that they’ll now not make full viruses and subsequently can’t infect others.

Nonetheless, if you’re contaminated with a retrovirus equivalent to human T-lymphotropic virus (HTLV-1), HIV HBRV or Borellia as in power Lyme illness and develop DNA methylation and immune dysfunction, these endogenous retroviruses start to be expressed, and that is yet one more actually vital discovering.

HIV — One Instance of a Transmissible Retrovirus

One instance of a transmissible retrovirus is the HIV virus, which may cascade into the medical signs of acquired immunodeficiency syndrome (AIDS). HIV was found in 1982, and as talked about above, was a part of Mikovits’ early analysis work. Her e book consists of the historical past of that vital discovery.

When Mikovits first started learning retroviruses, HIV/AIDS was utterly unknown, however they suspected a retrovirus was at play due to how retroviruses have an effect on the human immune system and result in acquired immune deficiencies and cancers.

“You do not simply sooner or later get this virus and also you’re sick. Actually, we now know thousands and thousands of individuals have HIV and can by no means develop AIDS. We speak about that within the e book, as a result of the e book in the end is one in every of hope that we repair HIV.

I can actually let you know in 1999, once I was working the lab of antiviral drug mechanisms, I didn’t ever anticipate we might remedy that downside. Now, AIDS sufferers on antiretroviral remedy are most likely more healthy and develop fewer cancers … than a lot of the remainder of society.”

Some retroviruses, together with XMRV (however not HIV), additionally infect your germ cells, which implies they not solely trigger steady an infection in your physique but in addition switch to your offspring.

“XMRV, the xenotropic murine (mouse) leukemia retrovirus, is the mouse-related retroviruses that trigger most cancers and plenty of neurological ailments. These have an effect on the stem cells, the egg, the sperm — each cell in your physique. That was one of many large ‘Oh, my Gods,’ about our discovery,” Mikovits says.

Relating to therapy, the secret’s to maintain the virus silent, as a result of once they’re not, every time your cells divide you make extra retroviruses. For this, antiretroviral remedies are used, a few of which shall be mentioned later on this article.

From AIDS to ME/CFS

After 9/11, Mikovits began working with a lady whose daughter was severely sick with power fatigue syndrome. “Principally, that was the primary time I ever noticed the illness referred to as ME/CFS,” she says.

“This individual was a herpes virus often known as human herpesvirus 6 (HHV-6). This can be a virus distinguished in folks with Kaposi sarcoma, [which] grew to become related to HIV and AIDS. Dr. Patrick Moore and Dr. Yuan Chang [discovered] that Kaposi sarcoma was really attributable to a herpes virus — then often known as Kaposi sarcoma herpes virus; now, it is HHV-Eight.

As a result of the immune system is crippled, you get up the sleeping herpes viruses. Individuals with autism, ME/CFS and cancers have numerous power energetic infections, so we frequently see the Epstein-Barr virus (EBV) related to outbreaks of ME/CFS …

This lady launched me to Dr. Dan Peterson and Annette Whittemore in Incline Village, Nevada, the place he had been learning outbreaks of ME/CFS for most likely 25 years. He mentioned he had a financial institution of samples. We went up there. I met all of the sufferers.

I interviewed them in nice size and developed a speculation, which had really been proven earlier than by Elaine Defreitas, Ph.D., one other scientist a few years earlier …

Defreitas had remoted retroviruses from sufferers with ME/CFS. A physician … named Sidney Grossberg had additionally remoted retroviruses from at the very least one affected person with ME/CFS. So, the retroviral speculation wasn’t new. All the things about it match …

Probably the most severely injured sufferers at the moment was Whittemore’s daughter, Andrea. That summer season (2006), I went up there … and began learning it … I used the programs biology strategy, as a result of there’s numerous heterogeneity.

We all know AIDS sufferers who’ve HIV and can by no means get AIDS … I interviewed sufferers in Peterson’s workplace all summer season and took blood, urine, saliva and every kind of samples to isolate that virus, which is what it’s essential to do to point out it is related to a illness.”

The Discovery of Infectious Retroviruses

Finally, she introduced collectively a number of of her former and present colleagues who have been world specialists in HIV sequencing to take a look at ME/CFS. Amongst them was the world’s main electron microscopist, Kunio Nagashima, who has carried out the electron micrographs of each household of human retroviruses found: the human beta retrovirus, human delta virus, lenti-virus (equivalent to HIV) and gamma retroviruses.

Working in collaboration with the Cleveland Clinic, Mikovits and her workforce remoted the virus and spent the higher a part of 2008 and 2009 placing a paper collectively, proving the XMRV retrovirus was infectious and transmissible and never simply one other crippled human endogenous retrovirus.

“To our horror, we realized these [retroviruses] could possibly be aerosolized. This was in 2011 … That was actually the primary nail in my coffin. Pun supposed, as a result of the nationwide academy member, John Coffin, Ph.D. — who had informed Frank Ruscetti, ‘There is no such thing as a such factor as human retroviruses. Do not research them’ — then made a fortune out of HIV and did every little thing he may to destroy me and the sufferers,” Mikovits says.

“Previous to publication in 2009, we wrote a patent on the detection of those retroviruses, these items and components as contaminants of the cell cultures, of the cell strains from which we make vaccines. After they destroyed my fame and profession and compelled the retraction of our paper from [the journal] Science, Coffin circled and wrote a patent on the detection of those viruses in contaminating cell linings and contaminating biologicals in our labs.”

This PDF consists of emails, letters and supporting documentation displaying how the retraction of Mikovits’ Science paper was compelled, after which Coffin filed his personal patent for a detection technique of the contaminants in cell strains used for vaccines and different biologicals. There’s additionally documentation detailing the scientific fraud Mikovits asserts on this interview.

Infectious Retroviruses Might Contaminate Blood Provide and Vaccines

In her e book, she additionally particulars how infectious retroviruses are nonetheless seemingly infecting many organic options used clinically immediately, equivalent to vaccines and different therapies. To say that it is a concern can be an understatement. Kids’s Well being Protection discusses this, and extra, in “Trying Again, Trying Ahead: Most cancers and Vaccines.”1 Mikovits explains:

“That was actually on the coronary heart of the massive ‘Oh, my God.’ The worst I realized on this complete expertise is how corrupt scientific journals are. Actually, Ruscetti now calls Science, that prestigious journal, ‘The Nationwide Inquirer,’ as a result of they actually engineered the entire thing to destroy MEC/FS sufferers and any affiliation this virus [XMRV] had with these ailments …

All the research confirmed that the management inhabitants was between three.75 and 6.Eight % contaminated. While you do a research and there is proof of an infection in 6 % of the human inhabitants, that is 25 million Individuals. To place that in context, on the peak of HIV/AIDS in 1995, it was 1 million Individuals. It could crush our well being care system in the event that they needed to pay for what they brought about.”

The results of Mikovits’ findings was nothing wanting private devastation. Not solely was her paper retracted by Science, she was even arrested for “stealing” her personal lab notes. Costs have been in the end dropped, however the harm to her fame was a carried out deal.

“Principally, our paper got here out on October Eight, 2009. It was actually like ‘the shot heard world wide.’ I used to be on the street each single day. All over the place I went medical doctors have been like, ‘She’s acquired it. She’s acquired it. She’s acquired it,’ and never simply with MEC/FS but in addition with most cancers, leukemia, lymphoma, with prostate most cancers.

While you begin trying on the inflammatory occasions within the acquired immune deficiencies, with autoimmune illness, with Lou Gehrig’s illness, the issue grew to become this [retro]virus. Properly, there isn’t any single virus. There is not any HIV. There’s a complete household of HIVs. There’s an HIV 1. There’s an HIV 2. There is a pressure A, B, C and D.

Why can we do influenza vaccines for this pressure de jour or yearly? [Because] there are strains of viruses. There are households of viruses … The second that we revealed this paper, we began working to get a diagnostic check for the blood provide to point out it wasn’t contaminated, which, in truth, it was.

Later that yr, the final speak I ever gave was on a science paper that got here out September 22, 2011 … That speak was principally a debate for the proof that there are human retroviruses of the XMRV household that are not VP62 (the infectious molecular clone, not the pure isolates of our paper).

We may present within the unique paper that there was proof of murine leukemia viruses, gamma retroviruses that have been infectious and transmissible, simply as we had mentioned.

Coffin was on the opposite finish of that debate. He mentioned it was all a recombination occasion. He revealed a paper in 2013 saying, ‘After we labored with mouse cells, they expressed numerous items and components of retroviruses. This simply occurred to occur within the laboratory.’

[Hence, he claimed] that is what we had remoted. [Coffin claimed] that what we have been have been simply contaminants within the laboratory. ‘It is all a lab contaminant,’ [Coffin said], ‘You possibly can all go residence. You are secure.'”

Huge Public Well being Issues Swept Beneath the Rug

As one would possibly anticipate, Mikovits’ analysis brought about large concern within the skilled group, as a result of right here was a newly recognized, infectious and transmissible retrovirus that nobody was screening for, and it was probably contaminating 10 % of the human blood provide. However somewhat than face the issue head on, it was quickly swept underneath the proverbial rug.

“My mother was watching Good Morning America one morning. Throughout the underside of the ticker tape mentioned, ‘XMRV all a hoax’ … It was horrible. We began to comprehend our pretend information and faux science.”

Immediately, the blood provide is unlikely to be contaminated, due to a decontamination process developed by a California-based firm referred to as Cerus and which Mikovits proved to inactivate XMRV, rendering it noninfectious.

Different biologicals, together with vaccines, nonetheless, might not be routinely decontaminated utilizing this course of, largely as a result of they’re not required to take action, and drug corporations will not be answerable for vaccine-induced hurt. What’s extra, decontaminating the vaccine might render it ineffective.

“It gained’t work. It’ll now not be a vaccine … The Cerus technique cleans up Ebola. It cleans up Zika. It cleans up primarily any RNA viruses, together with HIV and all three human retroviruses. The Cerus system is extraordinarily helpful to cleansing up the blood provide.

However they can’t clear up the vaccines for one more cause. In the event that they do, they show Andy Wakefield proper. They show me proper. They show they have 25 million Individuals, who they need to assist for the remainder of their lives and pay damages [to] …”

The Worth of Making an Unpopular Scientific Discovery

On a private stage, Mikovits has taken an unlimited private hit. September 29, 2011, she was fired from the Whittemore Peterson Institute for insolence and insubordination, and was pushed out of business after being falsely arrested for stealing her personal lab notes. (She by no means was and to this present day is just not in possession of her notebooks or any of the 2 places of work stuffed with her work carried out in her whole profession.)

She explains her firing saying that Whittemore had been promoting a diagnostic check and the director of their for-profit industrial laboratory was utilizing federal grant funds to try this work (with full information and underneath the path of Annette and Harvey Whittemore), which is misappropriation of federal funds. Mikovits grew to become conscious of this in August that yr, and wrote him off the grant.

“The Whittemores principally fired me instantly in an try … to get this scientist, Vince Lombardi, Ph.D. … to recreate the work whereas I used to be out of city and say I used to be a lunatic — that he’d been doing the work all alongside, and he hadn’t misappropriated any of the funds.

They fired me on September 29 and instantly locked down the whole college to me or my employees … The insolence and insubordination was I had refused a direct order to misappropriate federal funds, principally. I wasn’t ever going to try this. The insolence I am making an attempt to study to not do, as a result of it most likely would have gone loads higher for me if I did not say ‘F-you,’ on the identical time …

It was September 22, 2011, once I gave my final speak. That they had three weeks to get a Science paper on the market that may destroy my fame within the ME/CFS group … Ruscetti needed to signal that paper, or he and Sandy Ruscetti can be fired … [and] lose their whole retirement, which is 75 years.

That was one of many few instances I sobbed. I used to be sitting in my mattress screaming …It was 6 o’clock within the morning. They have been on the East Coast and so they wanted to get this paper revealed quick by Science.

I referred to as the Ruscettis and mentioned, “Frank, they agreed to vary the language. They agreed to vary the title. They agreed it wasn’t an affiliation research … [they say] we did not have a diagnostic check. Both means, the Whittemores are going to kill me as a result of they’re promoting the diagnostic check.’

So Frank [Ruscetti] signed the paper. They did not change the wording. [What they did] is pure fraud. Right here, the top of the Nationwide Coronary heart, Lung, and Blood Institute revealed pure fraud within the journal Science, simply as two years later, Ian Lipkin revealed pure fraud. It’s pretend information. It’s so corrupt, every little thing about it.

It is not [the researchers]. It is the highest of the road. It is Dr. Tony Fauci. We’re solely allowed to make incremental advances. While you make a discovery of this nature, it adjustments all of every little thing. That is misogyny … This can be a bunch of little boys … combating over who will get credit score, whereas the world dies, when you kill a whole continent.

That is why I do exhibits like this. As a result of we will train medical doctors. When medical doctors perceive the science — and so they’re coming round loads — as a result of the science is there. Nothing about our paper, besides the sequence of the virus, has ever been mistaken. We knew that at first.”

People Contaminated With Retroviruses Ought to Keep away from Vaccinations

Based on Mikovits, retroviruses equivalent to XMRV have an effect on whole households, as it may be transmitted to your offspring. Many of those households even have kids with autism, which Mikovits believes could also be linked to the retrovirus. The query is, what are you able to do in case you’re contaminated? For starters, Mikovits recommends avoiding vaccinations.

“Till 2011, not inconsequentially, we did not vaccinate AIDS sufferers the identical means. It is within the e book. You do not vaccinate the immune-compromised … By definition, you might have an immune system that does not work. Why would you vaccinate them? Why would you vaccinate someone underneath three years previous, who has an immune and detox programs that do not work?

This was the important thing of the RNaseL story (a genetic susceptibility to not degrade RNA viruses), of the Thompson fraudulent paper [Editor’s note: This refers to William Thompson, Ph.D., a former senior scientist at the CDC’s National Center for Immunizations and Respiratory Diseases, who confessed he conspired to cover up links found between the MMR vaccine and autism].

All they needed to do was look forward to black boys to be three years previous, and they’d have been capable of degrade the RNA virus. That is felony. That is past comprehension …

The pearl of knowledge is that this DNA methylation. Hold the violent virus silent … DNA methylation has to silence them. You possibly can’t inject them in a vaccine. We’re injecting thousands and thousands of items in components of retroviruses in each vaccine, by definition (and admission).

I’m engaged on an ongoing most cancers lawsuit that claims vaccines trigger childhood most cancers, a lymphoma. By these identical mechanisms, you’ve got destroyed the DNA methylation equipment’s capability [to silence the virus]. You have merely overwhelmed the substrate. You have overwhelmed the power to methylate.

Each time these viruses combine, you might have a greater probability at insertional mutagenesis. Do not expose anyone to human (or animal) retroviruses. Use antiretroviral remedy, that are pure merchandise … There are many pure merchandise. We revealed on them. These are literally remedy for these youngsters.

[A 100-year-old drug called Suramin] was one of many first antiretroviral therapies for HIV … [It] labored greatest towards the murine leukemia virus-related viruses, towards the mouse retroviruses, the gamma retroviruses …

[Dr. Robert] Naviaux [professor of medicine, pediatrics and pathology at University of California San Diego School of Medicine] did a small medical trial.2 These youngsters acquired their life again.three They began speaking once more. What did Bayer do? They stopped the trial and took the drug away from everybody. Now, you’ll be able to’t get it …

We may assist thousands and thousands of individuals recover from [autism]. However if you present treatment, you understand trigger. That is it. I might be proper … Tens of millions of individuals would get their lives again, and it is all about cash.”

XMRV Is a Important Risk

As talked about, there are a number of totally different retroviruses, that are a part of 4 viral households (delta, lenti, beta and gamma). Except for HIV and XMRV, there’s the human T-cell leukemia lymphoma virus (HTLV-1) household. There are 5 – 6 HTLV viruses, however HTLV-1 is the one one recognized to trigger extreme illness.

Human beta retrovirus is one other virus related to major biliary cirrhosis. Many sufferers with MEC/FS even have members of the family with major biliary cirrhosis. As for which one may be essentially the most important menace, Mikovits believes XMRV is among the many most urgent, as a result of whereas HIV is well-contained at current, XMRV is just not, and it seems to play a major function in ailments of methylation.

Disturbingly, they’re now utilizing murine leukemia viruses as vectors for gene remedy and a novel most cancers remedy referred to as chimeric antigen receptor (CAR) T-cell remedy. In different phrases, they’re inflicting most cancers and different retroviral sicknesses.

“The identical factor with Gardasil … We’re inflicting these ailments and we all know it as a result of we’re utilizing these [retroviruses] as vectors. We do not want infectious viruses. That is one factor that is actually vital to know. You do not want infectious viruses in case you’re injecting the provirus, or the items and components. You inject it, previous your immunity, previous your intestine, previous RNA cell, previous every little thing. You bypass the immune system. They do not should be infectious.

All you want is an envelope to trigger that prostate most cancers. That is a paper that was revealed 2013. In most of our research, all we detected was the envelope. The envelope alone causes vasculitis … One other pressure of XMRV gamma retrovirus from mice was recognized by Gary Owens … related to heart problems. That is only a nightmare that we have unleashed in our surroundings.”

Retroviruses and ME/CFS

Based on Mikovits, 6 to eight % of the final inhabitants are contaminated with infectious and transmissible XMRV-retroviruses, and within the power fatigue inhabitants, that prevalence shoots as much as about 30 to 40 %. As with HIV, antiretroviral therapies could be very useful within the therapy of ME/CFS, together with low-dose naltrexone.

“It’s important to silence the opposite pathogens, so caring for mycoplasma, caring for mould, completely supporting the intestine microbiome [will help],” Mikovits says. “We realized with AIDS and most cancers sufferers that if they do not have the range within the microbiome, identical to in autism, identical to in MEC/FS, it is as a result of the retrovirus is inflicting leaky intestine …

The nonspecific irritation [is] the retroviruses. When you maintain the intestine wholesome, you’ll be able to heal. The first is the range within the microbiome, or you’ll be able to’t reply to the medicine. There’s numerous hope. That is what we finish the present with. There are therapies. We may repair this tomorrow. That is why I do it.”

To study extra, be sure you choose up a replica of “Plague: One Scientist’s Intrepid Seek for the Fact About Human Retroviruses and Continual Fatigue Syndrome (ME/CFS), Autism and Different Illnesses,” which reads extra like a fictional thriller than a nonfictional e book in regards to the science of illness.

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